Flights will depart Narita at 1115, arriving in Brussels at 1515. The return service will then leave at 2050, getting back into Tokyo at 1610 the following day.
The route was first announced earlier this year, but this is the first time details of the launch date, schedule and aircraft type have been confirmed.
“As a major economic, commercial and political centre, Brussels is an increasingly important market for us,” said Osamu Shinobe, president & CEO of ANA. “More and more passengers are flying between Tokyo and Brussels but they currently have to do so by transiting through other cities.
“By becoming the only Japanese airline to offer direct flights to the city, ANA will dramatically improve access for passengers to and from Japan,” he added.